Can I Mix CBD Oil With Melatonin


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One type of sleep aid gaining notoriety as of late are CBD products with added melatonin. Melatonin is a naturally occurring hormone that helps our bodies fall asleep. But is it safe to combine melatonin with CBD oil? Taking CBD oil and melatonin together is largely considered safe, and may be more effective at beating insomnia than taking the supplements on their own

Mixing Cannabidiol (CBD) with Melatonin: What We Know

One type of sleep aid gaining notoriety as of late are CBD products with added melatonin. Melatonin is a naturally occurring hormone that helps our bodies fall asleep. But is it safe to combine melatonin with CBD oil?

Alexa Peters is a Seattle-based freelance writer and editor with a specialty in arts & culture, wellness, and lifestyle journalism, as well as content writing. My cannabis and CBD-focused work has appeared in Leafly, CannabisMD, Healthline, Green Valley Nation, and many other publications.

Here are our key findings:

  • CBD research into sleep is still preliminary, but has shown promise in some people for treating insomnia
  • Melatonin can help regulate sleep and wake cycles in some people
  • Mixing Melatonin and CBD is generally safe and several combination products are available
  • Certain populations, including pregnant women, those with seizure disorders, diabetes, or anyone taking blood pressure medications are advised to consult their doctors before using melatonin

What We Know About Cannabidiol (CBD) and Sleep

50 to 70 million Americans suffer from chronic insomnia every year. That could be why the sleep aid market is estimated to be worth $162.5 billion by 2030.

Despite its retail popularity, the data available on CBD for sleep “ is in its infancy ,” according to researchers.

There is some information on the behavioral effects CBD can have, though. Authors of the aforementioned paper sought out to investigate CBD’s role on anxiety and sleep quality in 103 adult patients. They discovered that sleep scores improved for 66.7% of patients in the first month but fluctuated over time.

Another clinical trial comparing CBD with Nitrazepam, a benzodiazepine with hypnotic properties, found administration of doses of CBD 160 milligrams or higher significantly increased the duration of sleep . Other studies show that cortisol levels decrease with CBD administration at doses as high as up to 600 mg . The decrease in cortisol levels yielded a sedating effect for patients.

Another review of the literature on cannabinoids like CBD for sleep published in 2017 “suggests that cannabidiol (CBD) may have therapeutic potential for the treatment of insomnia” as well as showing promise for REM sleep behavior disorder and excessive daytime sleepiness.

While CBD’s exact mechanism of action is still unknown, the working theory behind how CBD works for sleep suggests its reduction in anxiety plays a part.

CBD can also impact sleep by helping our bodies’ endocannabinoid systems better maintain circadian rhythm. Circadian rhythm is the internal process by which our bodies regulate our sleep and wake cycles. Available data suggests endocannabinoid signalling is implicated in the circadian process , and if we know CBD impacts our endocannabinoid systems its possible CBD can , “…serve as a chronobiotic [an agent that can cause phase adjustment of the body clock] therapeutic compound for individuals with disrupted circadian function.”

In other words, if your body struggles to naturally wake and fall asleep every day, CBD may be able to help.

What We Know About Melatonin and Sleep

Melatonin is a naturally occurring hormone. Produced by the pineal gland at night, its primary function is to regulate circadian rhythms and help promote sleep.

Melatonin’s reputation catapulted it to becoming one of the most popular dietary supplements on the market today. It’s marketed as a sleep aid, but is the research there to support the idea?

Yes and no. A 2021 review examining the safety and efficacy of melatonin found that melatonin could advance the time of sleep onset—making you feel sleepy more quickly—but the effect was “modest and variable.”

“Most people’s bodies produce enough melatonin for sleep on their own,” explains sleep expert Luis F. Buenaver, director of the Behavioral Sleep Medicine Program at Johns Hopkins’ Department of Psychiatry and Behavioral Sciences. “However, there are steps you can take to make the most of your natural melatonin production.”

Buenaver recommends using melatonin supplements for a specific set of circumstances—on a short term basis for insomnia, overcoming jet lag or for those looking to fall asleep and wake up earlier.

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Can I mix CBD and Melatonin?

Though there is little to no research into the long-term effects of combining cannabis and melatonin, the general consensus from brands and consumers who create CBD and melatonin products have found that, generally, yes, you can combine CBD and melatonin safely.

That said, according to Leaf Report Medical Reviewer Eloise Theisen, MSN, AGPCNP-BC, melatonin should only be used for the short term and is not considered a long term solution to sleep issues.

“If you need help staying asleep rather than falling asleep, the addition of melatonin may not be necessary. Melatonin can cause a drugged, groggy effect in some and may not be necessary to add to a CBD regimen for sleep,” she said.

At Elevated Wellness , a CBD brand founded by health care professionals based in Austin, TX, their CBD-melatonin products are some of the brand’s top sellers. In using these products, the brand’s Marketing Manager Daniel Britt stresses the importance of understanding dosing is unique to each person.

“It’s not just about weight, which is what we first assume because of other pharmaceuticals,” says Britt. “It actually doesn’t have to do as much with weight as it does with body chemistry.”

Finding the right dose then, can take some trial and error. Going overboard on dosing can result in “hangovers” the next day, or feelings of immense grogginess that can accompany too much CBD or melatonin, says Britt. In fact, Thiesen adds, “CBD can be stimulating at low doses, so adding in melatonin may counteract that effect and make low-dose CBD more suitable for sleep.” So, you shouldn’t require a super high dose of CBD-melatonin product to see effects.

Thus, experts like Britt suggest a low and slow approach to trying CBD and melatonin—especially if you already know you’re very sensitive to CBD or melatonin’s effects. For instance, Elevated Wellness’ products suggested dose is 1 ml of the tincture under the tongue, but if you are concerned about how it might affect you—do half of that and increase from there based on how you feel.

Additionally, both Thiesen and Britt emphasize that if you have never taken CBD or melatonin before, it is best not to mix them until you have tried them separately to see how you respond to them individually.

“It may be wise to try CBD products without melatonin first to see how that works for you,” said Britt, adding that taking the two together may enhance the strength of the overall effect.

Thus, in the end, melatonin may not be necessary to add to a CBD regimen for sleep, Thiesen says.

How to find quality products containing CBD and Melatonin

In addition to taking a “low and slow” approach to dosing, it’s essential consumers ensure the efficacy and safety of their CBD/melatonin product by vetting its quality. Here’s how:

  • Ensure the safety and quality of your CBD/Melatonin product by checking out the companies’ reputation here at LeafReport’s Brand Reviews and/or by ascertaining if the company has been issued an FDA warning letter .
  • Look over the lab reports produced by the company. Here are some points to look for in the “ Certificate of Analysis ” or CoA.
  • Make certain that the lab used has a state license, is ISO accredited and that the CoA is signed and dated—this information is usually found on the last page and sometimes in a header or footer.
  • Make sure the product received a “passing grade” when it comes to the levels of heavy metals, pesticides, microbials, mycotoxins, residual solvents and debris.
  • Look for less than 0.3% THC in the product. This is the legal limit for THC in any CBD product. This is especially important for those concerned about drowsiness or other undesirable side effects of cannabis.

Elevated Wellness, for instance, third-party tests both their CBD and the melatonin that they use in their combination products, and they source all the extracts used in their products from pharmaceutically regulated labs to ensure the utmost quality of their products. They also third-party test for heavy metals, pesticides, microbials, mycotoxins, residual solvents and debris.

All of this information is readily available on their website, or through contacting their team for a CoA—and that’s the kind of transparency you want in whatever brand you’re purchasing your CBD/melatonin product from.

Safety of CBD and Melatonin

Certain populations, however, are not advised to use melatonin including pregnant women, those with seizure disorders, diabetes, or anyone taking birth control pills, blood thinners, or blood pressure medications. Some melatonin supplements can raise blood pressure levels in those taking certain medications.

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This can be a risky interaction with CBD as a 2017 research study found taking CBD with antihypertensive medications may change blood concentrations of either substance. The same goes for taking CBD and blood thinners.

As such, at risk populations should speak to a healthcare professional before using products that contain CBD and melatonin.

Melatonin and CBD Oil: Can It Help You Sleep Better?

When looking for better sleep, people will try just about anything. For years, science has supported the use of melatonin in cases of insomnia and other sleep disorders. But recently, CBD oil has been gaining traction as a potential solution to a range of problems, including sleep disturbances.

When combined, do CBD oil and melatonin help you sleep better? Are there side effects of using CBD oil and melatonin together? Moreover, how can you use CBD oil and melatonin safely?

In order to get the most from any supplement routine, it is important to understand the answers to these questions. Here’s what you need to know about CBD oil, melatonin, and getting a good night’s sleep!

CBD Oil and Melatonin Interaction

Melatonin and CBD oil both promote sleep, but work in different ways to do so. Unlike regular vitamins and supplements, when you take melatonin it is treated by the body as if it were created internally. Instead of breaking it down and converting it into something usable, your body is able to metabolize melatonin immediately, without further processing. The same is true for CBD oil.

CBD replicates your body’s own endocannabinoids in order to exert its therapeutic effects. Melatonin supplements work in a similar way, replicating endogenous melatonin to regulate your circadian rhythm, or natural sleep-wake cycle.

During normal waking hours, there is very little melatonin circulating in your body. Instead, there are other hormones like cortisol at work, which keep you alert and awake. As day turns to night and natural sunlight levels drop, the levels of melatonin in your system start to rise as the sun goes down, peaking overnight and slowly reducing toward the morning. Taking a melatonin supplement before bed increases the amount of melatonin in the body and can encourage rest and deeper sleep.

CBD oil promotes sleep by reducing cortisol levels and anxiety . Cortisol levels should naturally fall overnight, but if you’re overly stressed, they can spike and remain high, making falling asleep near impossible. CBD oil has been shown to inhibit the release of cortisol , and could help reduce the stress that’s barring you from a good night’s sleep. Since CBD oil can also help with anxiety, your overall stress levels should dip and remain lower, making relaxation and a good night’s sleep more achievable.

With all this in mind, taking CBD oil and melatonin together may create a powerful aid to fight insomnia. Because cannabidiol and melatonin act on different systems in the body, currently, the two substances can act synergistically to enhance the quality of your sleep. Melatonin signals your body that it is time to sleep, while CBD oil works in tandem to provide overall relaxation and calm. Together, they deliver a one-two punch to insomnia and sleep disturbances.

Side Effects of Using CBD oil and Melatonin

Neither CBD oil or melatonin have many recognised side effects. CBD oil is widely considered to be safe with little to no side effects . The World Health Organization published its own report on the use of CBD oil and found, “ … CBD does not produce the effects that are typically seen with cannabinoids such as THC… it is generally well tolerated, with a good safety profile.” Melatonin has few reported side effects , but some users may experience headaches, depression, or irritability. Combining CBD oil and melatonin may mitigate some of these side effects.

Long-term use of melatonin is discouraged, as its efficacy decreases with chronic use. Courses of melatonin should be limited to three months or less. CBD can be used more chronically. If you decide to use the two supplements together, you may find that using both melatonin and CBD initially helps to establish good sleep patterns. Once these sleep patterns have been established, you could decrease your regimen to include CBD only.

Limited use of melatonin can help regulate your sleep-wake cycle, similar to hitting the refresh button on your natural circadian rhythm, times when your sleep cycle may be disrupted e.g. after international travel across time zones Regular use of CBD oil can regulate the body’s cortisol production, so you’ll feel less stressed day and night, which is great for your sleep hygiene and overall well being.

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Melatonin and CBD are both metabolised via the cytochrome p-450 pathway, so any side effects of melatonin may theoretically be exacerbated by adding CBD. Perhaps you should include a warning about this and just a recommendation to start with a low dose of CBD if you are adding it to an existing melatonin supplement.

How to Safely Use CBD Oil and Melatonin Together

When combining CBD oil and melatonin it’s important to take dosage into account. As melatonin is often purchased in standardized doses it is easiest to maintain this amount and add CBD oil into your routine gradually. Start with a low dose of CBD oil and slowly increase your dosage over time if necessary—you don’t want to overload the body with too many sleep-inducing compounds at once. Allow your body and mind time to adjust to the effects of CBD oil.

Take note of whether taking CBD oil throughout the day or just at night is more beneficial for promoting sleep. You might consider keeping a sleep journal for the first month of using CBD oil and melatonin together to gauge which dosage and at what time(s) of day are most effective when it comes to using CBD for sleep.

Alternatively, you can purchase CBD products that already have melatonin included. This removes the need to delicately balance your quantities. If using these products, start with the dosage suggested in the information pamphlet and gradually increase until you experience the desired effect.

Melatonin is best used when you can get a full 8 hours of sleep. To avoid feeling groggy in the mornings, take your melatonin or CBD oil/melatonin combination product when you have enough time to devote to sleep. As with anything that can promote or induce sleep, be careful driving, operating heavy equipment or doing anything that requires extreme concentration until you know how the combination will impact you.

As a precaution, speak to your doctor before combining the two supplements. You can also speak with a cannabis doctor who can give you personalized recommendations on dosages and specific CBD products to help with sleep.

Best CBD Oil to Use with Melatonin

If you’re ready to try a product that contains CBD oil and melatonin, or want to purchase CBD oil to add into your existing melatonin routine, there are two main factors to consider: delivery method and quality.

For a melatonin-CBD hybrid product, the most common delivery formats are combination gummies , capsules, tinctures , and drops . Simply take the recommended dose prior to going to bed. Because capsules or gummies travel via the digestive system, they take longer to take effect. For this reason, take your melatonin-CBD combo gummies or capsule about an hour before bed to ensure you’ll feel the effects right on time.

If you don’t know when you’ll be going to bed, or want a little more flexibility, sublingual CBD-melatonin drops or tinctures may be best for you. These CBD products are absorbed directly into the bloodstream through the skin under the tongue and go to work in as little as a half hour. The only difference may be that you don’t feel the effects as strong or for as long as you would a gummy or capsule.

If you are already taking melatonin and want to add CBD oil, try starting with drops or a tincture. This format will allow you complete control over your CBD dose, ensuring you can gradually increase or decrease the amount as needed.

Before taking melatonin, CBD oil, or a combination of the two, consult with your physician. By having this conversation, you can determine if these are safe options for you and work out a potential starting dose. Both CBD oil and melatonin can interact with some commonly prescribed medications .

If you don’t see effects immediately, don’t lose sleep over it! Be patient and take your time adding CBD oil to your daily or nightly routine.

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